Age does not Preclude an Esophagectomy…If Only it were that Simple

Population strategies for prevention? If only it were that simple!

Clustering is difficult only when it does not matter

Numerous papers ask how difficult it is to cluster data. We suggest that the more relevant and interesting question is how difficult it is to cluster data sets that can be clustered well. More generally, despite the ubiquity and the great importance of clustering, we still do not have a satisfactory mathematical theory of clustering. In order to properly understand clustering, it is clearly nec...

Salt-sensitive hypertension: if only it were as simple as rocket science.

Uncertainty in Model Predictions: Does it Preclude Effective Decision Support?

The uncertainty in the predictions of models for the development of environmental systems is usually very large. In many cases the width of predictive probability distributions for variables of interest is significantly larger than the difference between the expected values of the results for different policy alternatives. This seems to lead to a serious problem for model-based decision support...

Let's Face It—Complex Traits Are Just Not That Simple

1 Department of Cell Biology and Anatomy and the Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada, 2 Department of Mathematics, Florida State University, Tallahassee, Florida, United States of America, 3 Department of Orthopedics, University of California, San Francisco, San Francisco, California, United States of America, 4 Department of Pediatric...